This is a diverse collection, including correspondence, drafts of letters, notes and notebooks (on biometric methods; tables and formulae; science, nature and method; coefficient and correlation; vitalism; Japanese language); commonplace book (1924); autobiography; and over one hundred folders of unpublished writings. The correspondence and other material covers a variety of topics, including biology, eugenics, evolution and natural selection, human heredity, paramecia, protozoa genetics, U.S. immigration policy. There is much on the Seventh International Congress of Zoology (1907); letters to his father and wives, and from students and colleagues on his seventy-fifth birthday, 1943 (1 v.); diplomas and certificates of membership; and photographs.

Mostly concerned with Blakeslee's studies on beans, blood groups, colchicine, Datura, embryo cultures, and horticulture. Many letters relate to the support and direction of the Smith College Genetics Experiment Station, which he headed. Other letters are about the Carnegie Institution of Washington, "Biological Abstracts," American Association for the Advancement of Science, American Philosophical Society, Institut de France, University of Connecticut. Also contains travel letters from Germany and miscellaneous lectures.

The geneticist Milislav Demerec emigrated from Yugloslavia in 1919, spending nearly his entire career in the Department of Genetics at Cold Spring Harbor Laboratory. Working initially on the genetics of maize and later on Drosophila virilis, his research interests included radiation and chemical mutagenesis, and during the Second World War, penicillin and the genetics of antibiotic resistance. Demerec served as head of the laboratory at Cold Spring Harbor from 1941 until 1960. The Demerec collection contains the extant professional papers of Milislav Demerec, dating primarily from the time of his arrival at Cold Spring Harbor until his retirement. In addition to his correspondence with colleagues, the collection includes interesting material on the administration of Cold Spring Harbor laboratory during the 1940s and 1950s, data and research notes, material relating to professional organizations (e.g. Genetics Society of America, American Society of Naturalists), a lengthy series of lectures given by Demerec, and a large number of photographs pertaining to Demerec's research, but also to his colleagues and Cold Spring Harbor itself. There is also a Register of visitors to the laboratory (1927-1945) and a Milislav Demerec reprint list.